Scientific Head: Manzhulo I.V., senior researcher, Cand. Sci. Biol.
Main fields of research
The main field of research conducted by the Laboratory of Pharmacology is the development of novel drugs from marine organisms that have neurotropic, immunomodulatory, oncosuppressive, and detoxifying effects. The research is aimed at the development and identification of molecular and cellular mechanisms of action of natural and original modified lipid and polysaccharide compounds and a number of low-molecular-weight biological regulators. The Laboratory carries out studies on experimental pharmacology for such pathological states as peripheral and central nerve injury, tonic and neuropathic pain syndrome, glial tumors, neuroinflammation, and spontaneous and induced neurodegenerative processes. To date, the Laboratory has invented a series of biologically active preparations for the correction of neurodegenerative pathology ("Lipidomarin"), normalization of metabolic processes accompanying cardiovascular diseases ("Omegamarin"), treatment of pain syndrome ("Algamid"), correction of excess weight ("Oleamid"), and treatment of poisonings including those caused by radioactive compounds and heavy metals ("Polysorbovit" and "Detoxal"). Several novel compounds with potential anti-pain and anti-tumor effects, as well as complex protein/carbohydrate compositions for solving problems in regenerative medicine, are under development.
Approaches and methods used
Range of organisms and objects under study
Laboratory animals (mice and rats) and aquatic organisms from various systematic groups.
Information provided by the senior researcher I.V. Manzhulo.